Levetiracetam for Neuroprotection Against Corticosteroid-induced Hippocampal Dysfunction: A Proof of Concept Study
Completed · Phase 4
Conditions studied: Memory Loss Associated With Corticosteroid Use, Manic State Associated With Corticosteroid Use
In brief
The purpose of this research is to determine whether the memory impairment and manic symptoms (feelings of agitation, overexcitement or hyperactivity) typically seen in those on corticosteroid therapy is decreased with a seizure medication called levetiracetam compared to placebo (an inactive substance). Since increased levels of cortisol (the body's natural corticosteroid) in the body are frequently associated with memory impairment interventions that may prevent or reverse this are of great importance. It is hypothesized that patients who are scheduled to receive prescription corticosteroid therapy who are given levetiracetam pretreatment will show lesser memory impairment and manic symptoms than those receiving placebo.
Key facts
- Study ID
- NCT00223223
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 30
- Starts
- 2005-02-01
- Expected to finish
- 2005-11-01
- Last updated by the study team
- 2011-08-03
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-65 years
- Scheduled to receive a corticosteroid "burst" of at least 10 mg of prednisone equivalents and for at least 5 days duration
- English- or Spanish-speaking
You may not qualify if…
- History of allergic reaction or other contraindication to levetiracetam therapy
- Other unstable medical conditions (e.g. recent myocardial infarction, renal failure, diabetes with poor glycemic control)
- Pregnant or nursing women
- History of mental retardation, dementia or other severe cognitive disorders
Where it is running
- The University of Texas Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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