A Comparative Study of New Medications for Psychosis in Adolescents

Completed · Not applicable

Conditions studied: Psychotic Disorders, Schizophrenia, Schizophreniform Disorders, Schizoaffective Disorders

In brief

The overall goal of this study is to determine the efficacy and tolerability of three atypical antipsychotic medications (risperidone, olanzapine, and quetiapine) in the treatment of adolescents with psychosis. It is hypothesized that the three medications will be equally effective in reducing the symptoms of psychosis.

Key facts

Study ID

NCT00222495

Run by

University of Minnesota

People needed

30

Starts

2002-08-01

Expected to finish

2006-08-01

Last updated by the study team

2006-09-11

Who can join

Age: 12 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects are between the ages of 12-18 and have a diagnosis of a psychotic illness.
• Subject currently meets criteria for one of the following disorders: schizophrenia, schizoaffective disorder (mainly schizophrenic), schizophreniform disorder, and psychosis NOS.
• Subject is in good physical health and not suffering from any medical disorder that might mimic psychosis or lead to medical difficulty with the study medications.
• If subject is taking antipsychotic medication before study entry, their medicine will be discontinued for 1-4 days depending on symptoms.

You may not qualify if…

• Subject has a medical disorders that would interfere with the study, such as epilepsy, thyroid disease, liver disease, AIDS, etc.
• Subject currently has substance dependence.
• Subject is talking a medication that inhibits or induces the cytochrome P450 3A4 (specific medications listed in Appendix of protocol).
• Subject meets criteria for brief psychosis or mood disorder with psychotic features.
• Female subject is pregnant or nursing.

Where it is running

• University of Minnesota Medical Center — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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