Adjunctive Treatment for Decreasing Symptoms of Schizophrenia
Completed · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Schizophrenia, Schizoaffective Disorder
In brief
This study will determine the effectiveness of treatment with glycine or d-cycloserine in addition to a normal antipsychotic regimen in improving negative symptoms and cognitive impairments in patients with schizophrenia.
Key facts
- Study ID
- NCT00222235
- Run by
- University of Maryland, Baltimore
- People needed
- 240
- Starts
- 2000-01-01
- Expected to finish
- 2004-06-01
- Last updated by the study team
- 2019-08-20
Who can join
Age: 18 and older, up to 54. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- diagnosis of schizophrenia or schizoaffective disorder
- stable, enduring negative symptoms above a certain level (SANS >19)
- clinically stable, with psychotic symptoms measured on BPRS below 19, anxiety/depression on BPRS below 15
- extrapyramidal symptoms measured on SAS below 9
- on stable antipsychotic regimen (not including clozapine)
You may not qualify if…
- alcohol or substance dependence within last six months
- alcohol or substance abuse within last month
- organic brain disorder
- medical condition whose pathology or treatment could alter the presentation or treatment of schizophrenia, including active tuberculosis or tuberculosis treatment, kidney stones, and uncontrolled diabetes mellitus
- Female participants could not be pregnant and were required to be using a documented method of contraception.
Where it is running
- UCLA/VA Greater Los Angeles Health Care System — Los Angeles, California, United States
- Maryland Psychiatric Research Center — Baltimore, Maryland, United States
- Zucker Hillside Hospital — Glen Oaks, New York, United States
- Nathan S Kline Institute for Psychiatric Research — Orangeburg, New York, United States
- Ezrath Nashim Association, Sarah Herzog Memorial Hospital — Jerusalem, Israel
Full record on ClinicalTrials.gov
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