Can Additional Drug Therapy Accelerate Response Time to Antidepressants

Withdrawn before enrolling · Phase 4 · Has a placebo group

Conditions studied: Depression

In brief

Antidepressants are commonly prescribed and are effective for treating depression. However, they generally take 4-6 weeks for a therapeutic response. This study is evaluating whether simultaneous treatment with thyroid hormone or pindolol can decrease the response time ("getting better faster") in patients who are starting SSRI treatment.

Key facts

Study ID

NCT00221494

Run by

Mark Frye

People needed

0

Starts

2004-01-01

Last updated by the study team

2015-06-01

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients, male and female, between the ages of 18 to 65
• DSM-IV criteria for major depressive disorder
• No prior SSRI medication treatment (if a patient has discontinued a non-SSRI medication for side effects, they will not be excluded)
• Ability to be followed clinically for 6 weeks
• Each patient must understand the nature of the study and must sign an informed consent form

You may not qualify if…

• Severe suicidality (as defined by Beck Depression Inventory Question 9, responses 2 or 3)
• Major Axis I mental illness other than major depressive disorder
• Unstable medical health specifically cardiovascular disease, abnormal EKG, history of severe drug allergy, poorly controlled diabetes, and asthma (pindolol contraindication)
• History of thyroid disease or abnormal TFT's (stage I or II)
• Need for adjunctive antipsychotic use or additional benzodiazepine during the study
• Pregnancy
• Seizure disorder
• A positive urine toxicology screen

Where it is running

• UCLA Neuropsychiatric Institute — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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