C-reactive Protein (CRP)-Guided Management Algorithm for Adults With Acute Cough

Completed · Not applicable

Conditions studied: Cough

In brief

We aim to evaluate the impact of a CRP-guided management algorithm for adults with acute cough illness. More specifically, we will examine both process of care and clinical outcomes: 1. Processes of care (i.e., chest x-rays ordered, antibiotic treatment, length-of-time in the ED). We hypothesize that CRP-guided management will be associated with a decrease in the antibiotic prescription for acute cough illness from 50 percent to 30 percent. 2. Clinical outcomes (i.e., duration of illness, any return visit, return visit with a diagnosis of pneumonia, hospitalization, subsequent antibiotic use, satisfaction with care). We hypothesize that there will be no difference in the proportion of patients feeling back to normal within 2 weeks of their ED visit for acute cough illness (about 60 percent, 95% confidence interval=50 to 70 percent).

Key facts

Study ID

NCT00221351

Run by

University of California, San Francisco

People needed

139

Starts

2005-10-01

Expected to finish

2006-07-01

Last updated by the study team

2011-05-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults (age > 18 years) seeking care for an acute respiratory illness (duration < 10 days) in which cough is a chief complaint.
• Eligible patients will be required to have at least 1 symptom of acute respiratory tract infection (fever, night sweats, rhinorrhea, sinus congestion, myalgias).

You may not qualify if…

• Previous (within 21 days) antibiotic treatment;
• immunodeficiency;
• cystic fibrosis;
• patient requiring immediate evaluation/management;
• inability to provide informed consent.

Where it is running

• Truman Medical Center — Kansas City, Missouri, United States
• Veterans Affairs Medical Center — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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