Rabeprazole Protection of Aspirin Induced Gastric Damage.
Completed · Phase 4
Conditions studied: Normal Subjects
In brief
To determine the effectiveness of rabeprazole in preventing or decreasing acute gastroduodenal injury caused by therapeutic doses of aspirin in a placebo-controlled, randomized, double-blind parallel group study.
Key facts
- Study ID
- NCT00220857
- Run by
- Temple University
- People needed
- 30
- Starts
- 2005-09-01
- Expected to finish
- 2007-09-01
- Last updated by the study team
- 2008-01-11
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- A normal subject must be between 18 and 60 years of age with no history of gastrointestinal disease, gastroduodenal surgery, upper gastrointestinal symptoms or cardiopulmonary disease of any kind.
You may not qualify if…
- Normal subjects should have not ingested a salicylate, nonsteroidal antiinflammatory drug, histamine-2 receptor antagonist, proton pump inhibitor, misoprostol or carafate within one month of entering this study.
- He/she should not have participated in an investigational study within 3 months of this protocol.
- Pregnant women and women not using an accepted method of birth control will be excluded.
- Patients will be excluded who are allergic to aspirin and NSAIDs, who have an intolerance to aspirin and NSAIDs, who have a history of asthma and/or nasal polyps.
- Patients will be excluded if they have a history of gastric ulcers, duodenal ulcers, gastrointestinal bleeding, or bleeding disorder, clotting disorder.
- Patients will be excluded who actively abuse alcohol, as defined by greater than three twelve ounce beers or greater than three drinks containing hard liquor per day.
- Patients with a history of intracranial bleeding and/or brain trauma will be excluded from this research.
Where it is running
- Temple University School of Medicine — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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