Lactobacillus GG Supplementation During Pediatric Burn Injuries

Stopped early · Not applicable

Conditions studied: Burns

In brief

Critical illness and the therapies that accompany it are associated with a disruption in the ecological equilibrium of the GI tract that can ultimately lead to infection. Lactobacillus GG, a probiotic, replenishes the healthy flora of the intestinal tract and may decrease the risk of diarrhea and infection during critical illness. However, little is known about the impact of probiotics following a burn injury and the mechanisms behind the proposed benefits. The hypothesis of this research is that Lactobacillus GG decreases the incidence of diarrhea and infection in burned children receiving antibiotic therapy. The specific aim of this research is to determine the impact of Lactobacillus GG on the incidence of diarrhea and infection among burned children (\>20% TBSA) receiving antibiotic therapy.

Key facts

Study ID

NCT00220519

Run by

Shriners Hospitals for Children

People needed

3

Starts

2004-10-01

Expected to finish

2005-05-01

Last updated by the study team

2008-01-07

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Burn wound size of at least 20% of the body surface area
• Requires antibiotic therapy

You may not qualify if…

• < 20% total body surface area burn
• Does not require antibiotic therapy
• Only requires post-operative antibiotic therapy
• Bowel obstruction
• Milk allergy

Where it is running

• Shriners Hospitals for Children — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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