Effect of Menstrual Cycle on Central Nervous System (CNS) Processing of Gut Stimuli in Irritable Bowel Syndrome (IBS) and Control

Stopped early

Conditions studied: Irritable Bowel Syndrome

In brief

The hypothesis of the study is that women perceive intestinal stimulation (rectal balloon distention) differently in different phases of the menstrual cycle, i.e there is an effect of hormones on the sensory pathway, and that this difference is reflected in the Central Nervous System processing of this signal. We also hypothesize that there is a difference in perception between control subjects and subjects with the irritable bowel syndrome.

Key facts

Study ID

NCT00219531

Run by

Penn State University

People needed

48

Starts

1999-03-01

Expected to finish

2015-02-01

Last updated by the study team

2017-11-29

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• controls - normal bowel function
• Irritable bowel syndrome - Rome II criteria
• Normal menstrual cycle

You may not qualify if…

• irregular menses
• pregnancy
• use of psychotropic medication
• claustrophobia
• metal implants
• metal in eyes

Where it is running

• Hershey Medical Center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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