Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer

Completed · Phase 2

Conditions studied: Brain Metastasis, Non-small Cell Lung Cancer

In brief

The study objective is to evaluate the safety and efficacy of patupilone with respect to early progression and response of patients with non-small cell lung cancer (NSCLC) metastatic to the brain, who have progressed after chemotherapy, surgery and/or radiation.

Key facts

Study ID

NCT00219297

Run by

Novartis Pharmaceuticals

People needed

50

Starts

2005-11-16

Expected to finish

2010-06-24

Last updated by the study team

2021-02-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• World Health Organization (WHO) performance status of 0, 1 or 2 (corresponding to Karnofsky performance status of 50 or better)
• Patients with radiologically proven (by gadolinium-enhanced [Gd-] magnetic resonance imaging [MRI]) parenchymal brain metastases from histologically confirmed non-small cell lung cancer (the primary disease may be quiescent). Gd-MRI must be performed within 2 weeks of study entry.
• Patients should have at least one bidimensionally measurable intracranial lesion of a minimum of 2 cm as defined by Gd-MRI. If the patient has had previous radiation to the marker lesion(s), there must be evidence of residual disease > 2 cm or the lesion must have demonstrated progression since the radiation.
• Those patients progressing on radiotherapy must have a 25% increase in the size of the previously radiated intracranial lesion based on the Neuro-Oncology Criteria of Tumor Response for Central Nervous System (CNS) Tumors or appearance of new lesions.
• Patients must be controlled on medication and neurologically stable: stable on steroids and anticonvulsants for at least 2 weeks prior to obtaining the baseline Gd-MRI of the brain, and/or at least 2 weeks prior to beginning study treatment.
• Female patients must have a negative serum pregnancy test at screening. (Not applicable to patients with bilateral oophorectomy and/or hysterectomy or to those patients who are postmenopausal.)
• All patients of reproductive potential must agree to use an effective method of contraception during the study and for three months following termination of treatment.
• Written informed consent must be obtained.

You may not qualify if…

• Clinical evidence of leptomeningeal disease
• Patients with extracranial disease in more than 3 organ sites including the primary tumor.
• Patients who have received any investigational compound within the past 28 days or who are planning to receive other investigational drugs while participating in the study
• Prior administration of epothilone(s)
• Patients with peripheral neuropathy > grade 1
• Patients with unresolved diarrhea within the last 7 days before treatment.
• Patients receiving known diarrheogenic agents must stop treatment with these agents prior to enrollment in the study.
• Radiotherapy < 3 weeks prior to study entry
• Prior intracranial surgery < 3 weeks prior to study entry; patient must have recovered from surgery prior to study entry.
• Chemotherapy < 3 weeks prior to study entry; < 6 weeks from prior nitrosoureas.
• Severe cardiac insufficiency (New York Heart Association [NYHA] III or IV), with uncontrolled and/or unstable cardiac or coronary artery disease
• Radiotherapy not permitted while on study. Exception: palliative radiotherapy of metastasis in extremities is allowed, but such lesions cannot be used as target or non-target lesions.
• Patients receiving hematopoietic growth factors except for erythropoietin
• Patients taking Coumadin® or other agents containing warfarin, with the exception of low dose Coumadin® (1 mg or less daily) administered prophylactically for maintenance of in-dwelling lines or ports

Where it is running

• University of California Davis Cancer Center UC Davis Cancer (3) — Sacramento, California, United States
• Dana Farber Cancer Institute SC — Boston, Massachusetts, United States
• Wayne State University/Wertz Clinical Cancer Center Div. of Hematology/Oncology — Detroit, Michigan, United States
• St Louis University Cancer Center — St Louis, Missouri, United States
• Washington University School of Medicine-Siteman Cancer Ctr — St Louis, Missouri, United States
• Dartmouth Hitchcock Medical Center Oncology — Lebanon, New Hampshire, United States
• Roswell Park Cancer Institute — Buffalo, New York, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Columbia University Medical Center New York Presbyterian — New York, New York, United States
• Duke University Medical Center Dept. of DUMC (3) — Durham, North Carolina, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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