Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1

Completed · Not applicable · Has a placebo group

Conditions studied: Tobacco Use Disorder

In brief

Smokers report that they often smoke cigarettes during stressful times. The combined effect of smoking and exposure to stress leads to exaggerated increases in blood pressure, heart rate and other measures of stress response. This combination may result in greater cardiovascular harm than either smoking or stress alone. The purpose of this study is to determine the effects of paroxetine on the response to stress after smoking.

Key facts

Study ID

NCT00218439

Run by

University of Minnesota

People needed

105

Starts

2005-10-01

Expected to finish

2010-08-01

Last updated by the study team

2019-11-01

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Smokes an average of at least 10 cigarettes per day during the year prior to enrollment

You may not qualify if…

• Interested in quitting smoking within the 3 months following enrollment
• Current unstable medical condition
• Substance abuse within the year prior to enrollment
• Current use of any medications (e.g., psychoactive medications, antihypertensives) that, in the opinion of the investigators, might interfere with study measures or that would be expected to interact with paroxetine (e.g., CYP2D6 substrates)
• Smoking cessation therapy within the 3 months prior to enrollment
• Regular use of any form of tobacco other than cigarettes
• Significant psychiatric disorders as assessed by the PRIME-MD and verified by a clinician
• History of hypersensitivity to any selective serotonin reuptake inhibitor
• Pregnancy or breastfeeding

Where it is running

• College of Pharmacy — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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