Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia
Completed · Not applicable
Conditions studied: Hyperalgesia, Opioid-Related Disorders
In brief
Individuals who reduce or stop use of opioid medications are at risk for developing hyperalgesia, which is an increased sensitivity to pain. This study will compare the effectiveness of dextromethorphan, gabapentin, and oxycodone at reducing hyperalgesia in individuals addicted to opioids who are concurrently receiving methadone treatment.
Key facts
- Study ID
- NCT00218374
- Run by
- National Institute on Drug Abuse (NIDA)
- People needed
- 60
- Starts
- 2006-10-01
- Expected to finish
- 2007-06-01
- Last updated by the study team
- 2017-01-12
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Be between the ages of 18 and 55 years of age.
- Meets DSM-IV diagnostic criteria for opioid dependence
- Taking a stable dose of methadone for 6 weeks prior to study entry and is compliant in methadone maintenance treatment
- Is in good physical health or under a physician's care if a medical condition requires ongoing treatment
You may not qualify if…
- Known sensitivity to dextromethorphan, gabapentin, or oxycodone
- Currently dependent on alcohol, benzodiazepine, or any drug (other than nicotine)
- Currently in an acutely psychotic, severely depressed state and in need of inpatient treatment
- Immediate suicide risk
- Neurological or psychiatric illness (e.g., peripheral neuropathy, schizophrenia, neuropathic pain, Raynaud's disease, or urticaria)
- Acute medical condition that would make study participation medically dangerous (e.g., acute hepatitis, unstable cardiovascular disease, liver disease, or kidney disease)
- Liver enzyme values five times greater than normal
- Currently taking analgesic medication for a painful condition on a regular basis
- Current or past history of high blood pressure, heart disease, or stroke
- Currently using a pacemaker
- Pregnant or breastfeeding
Where it is running
- University of California, Los Angeles — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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