Treatment of Cocaine Dependence: Comparison of Three Doses of Dextro-Amphetamine Sulfate and Placebo

Completed · Phase 2

Conditions studied: Cocaine-Related Disorders

In brief

Dextro-amphetamine sulfate is a central nervous system stimulant that increases the release of the neurotransmitter dopamine in the brain. The purpose of this study is to further examine dose ranges of dextro-amphetamine sulfate as a treatment for cocaine dependence.

Key facts

Study ID

NCT00218348

Run by

The University of Texas Health Science Center, Houston

People needed

186

Starts

2003-09-01

Expected to finish

2007-11-01

Last updated by the study team

2017-12-19

Who can join

Age: 25 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• DSM-IV diagnosis of cocaine dependence, as determined by the Structured Clinical Interview for DSM-IV
• Agreement to use an adequate method of contraception for the duration of the study
• Electrocardiogram confirmation by a cardiologist
• Cocaine-positive urine test prior to study entry

You may not qualify if…

• High blood pressure
• Significant heart disease
• Clinically significant cardiovascular abnormality
• Angina
• Kidney, liver, or gastrointestinal disorder
• Current Axis I disorder not related to drug use
• Current dependence on any drug other than nicotine
• Attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD)
• On probation or parole for reasons other than those related to drug abuse charges
• Pregnant or breastfeeding
• Sought treatment for drug dependence within 3 months prior to study entry
• Currently taking prescribed medications

Where it is running

• The University of Texas Health Science Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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