Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

Completed · Phase 2

Conditions studied: Tobacco Use Disorder

In brief

Though spit tobacco is smokeless, it still affects the cardiovascular system and may be associated with heart disease, stroke, and high blood pressure. Long-term effects of smokeless tobacco (ST) include tooth abrasion, gum recession, mouth disease, loss of bone in the jaw, yellowing of teeth, and chronic bad breath. This study will assess the effectiveness of using tobacco free snuff in reducing levels of exposure to tobacco and associated toxicity, as well as enhancing motivation to either quit or sustain lower levels of nicotine intake.

Key facts

Study ID

NCT00218270

Run by

National Institute on Drug Abuse (NIDA)

People needed

138

Starts

2002-12-01

Expected to finish

2005-05-01

Last updated by the study team

2017-01-10

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Not interested in quitting smokeless tobacco use within 90 days of study entry
• Used smokeless tobacco at least six times a day for 6 months prior to study entry
• Agree to use an effective form of contraception throughout the study

You may not qualify if…

• Current use of tobacco or nicotine products other than ST
• Pregnant or breastfeeding
• Any unstable medical condition
• Use of any medication that may affect tobacco use or be affected by reduction of tobacco use
• DSM-IV diagnosis of any psychiatric disorders or substance abuse disorders within 6 months prior to study entry
• Use of any psychotropic medications within 6 months prior to study entry

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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