Progesterone for the Treatment of Cocaine Dependence - 1

Completed · Not applicable · Has a placebo group

Conditions studied: Cocaine Abuse, Cocaine-Related Disorders

In brief

Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high. The purpose of this study is to determine whether administered progesterone reduces subjective and physiological responses to cocaine in cocaine dependent individuals.

Key facts

Study ID

NCT00218257

Run by

University of Minnesota

People needed

96

Starts

2002-07-01

Expected to finish

2008-06-30

Last updated by the study team

2020-10-08

Who can join

Age: 18 and older, up to 46. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Smoked at least 1 gram of cocaine each week for the 6 months prior to study entry
• Agrees to use an adequate method of contraception for the duration of the study
• If female, current regular menses

You may not qualify if…

• Major psychiatric illnesses, including psychotic mood and anxiety disorders
• Current dependence on alcohol or drugs other that cocaine or nicotine
• History of major medical illnesses, including liver disease, abnormal vaginal bleeding, suspected or known breast cancer, thrombophlebitis, or other medical conditions
• Current use of oral contraceptives or other types of hormonal contraceptives
• Amenorrhea
• Currently on parole or probation
• Received treatment for chemical dependency within the 6 months prior to study entry
• Known allergy to progesterone or peanuts

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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