Treatment of Opioid/Heroin Dependence: Comparison of Three Medication Dosing Regimens

Completed · Phase 2

Conditions studied: Heroin Dependence, Opioid-Related Disorders

In brief

Heroin dependence remains a major addiction problem in the United States. The purpose of this study is to determine the effectiveness of levoacetyl methadol (ORLAAM) in treating heroin dependent individuals.

Key facts

Study ID

NCT00218127

Run by

National Institute on Drug Abuse (NIDA)

People needed

142

Starts

2001-11-01

Expected to finish

2005-07-01

Last updated by the study team

2017-01-12

Who can join

Age: 25 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Current opiate dependence
• Provides acceptable proof of identity
• History of 5 or more years of regular heroin use or dependence
• Reads and writes English

You may not qualify if…

• Significant suicidal or homicidal ideation, intent, or plan
• Current AXIS I psychotic, depressive, or anxiety disorder
• Meets DSM-IV criteria for dependence on any drug other than nicotine
• Impending legal complications or incarceration
• On parole or probation that requires reports of drug use or research data
• Currently receiving treatment for opiate dependence
• Currently participating in a 12-step substance detoxification program
• Medical condition that contraindicates administration of ORLAAM
• Plans to leave Houston, Texas within the year following study entry
• Pregnant or breastfeeding
• History of heart problems, including heart arrhythmias
• Requires psychotropic medications (e.g., antidepressants, antipsychotics, anxiolytics)

Where it is running

• Department of Psychatiry, Mental Services — Houston, Texas, United States

Full record on ClinicalTrials.gov

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