Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals

Completed · Phase 2 · Has a placebo group

Conditions studied: Cocaine-Related Disorders

In brief

Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this study is to examine the effects of d-amphetamine and modafinil, when given alone and in combination, in treating cocaine dependent individuals.

Key facts

Study ID

NCT00218062

Run by

The University of Texas Health Science Center, Houston

People needed

73

Starts

2006-03-01

Expected to finish

2012-01-01

Last updated by the study team

2017-06-21

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Meets Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV (SCID) criteria for cocaine abuse or dependence
• In general good health. Individuals who are HIV-positive will not be excluded if in good general health, unless medication interactions exist.

You may not qualify if…

• Meets diagnostic criteria for psychiatric disorders, including other forms of drug dependence, other than nicotine
• Current cardiovascular disease, as determined by an electrocardiogram
• On probation or parole if the circumstances do not allow study completion or if ethical constraints of supervision do not allow confidentiality
• Previously received treatment with d-amphetamine, modafinil, or aripiprazole
• Currently receiving prescribed medication

Where it is running

• University of Texas Health Science Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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