Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients

Withdrawn before enrolling

Conditions studied: Burns

In brief

Proline is a non-essential amino acid that helps with collagen formation. Collagen is one of the main ingredients of skin, bone, tendons, and connective tissue. It is thought that proline becomes depleted in burn patients because it is being used in greater than normal quantities to help the injured skin and connective tissue heal. If this is true, then the body must look for alternate energy sources as proline becomes depleted. This study aims to evaluate 1)the metabolic kinetics of the amino acids proline, glutamate, and ornithine and 2) the effects of glutamine supplemented total parenteral nutrition (TPN) on the metabolism of these amino acids.

Key facts

Study ID

NCT00217035

Run by

Massachusetts General Hospital

People needed

0

Starts

1997-08-01

Expected to finish

2010-01-01

Last updated by the study team

2017-01-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Burn patients being treated at MGH Burn Unit with one or more of the following criteria: 1) >=5% TBSA; 2) inhalation injury; or 3) resting energy expenditure (REE) of >15% of the predicted Basal Metabolic Rate using the Harris-Benedict equation.
• Must be receiving total parenteral nutrition in the course of their treatment.

You may not qualify if…

• Patients with thyroid disease. Patients who are not hemodynamically stable or show unstable vital signs Patients at the stage of major organ failure, e.g. renal and/or liver failure.

Where it is running

• Massachusetts General Hospital Burn Unit — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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