Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in Burns

Withdrawn before enrolling

Conditions studied: Burns

In brief

The Total Parenteral Nutrition (TPN)received as part of your routine burn care has optimal levels of protein and sugar, however the best mixture of amino acids for a patient with burn wounds is not yet known. Amino acids occur naturally in the body and the food we eat. The body combines amino acids to make protein. It uses the proteins to do things such as heal wounds, fight infection, and provide energy. We are studying if the body's use of protein is increased after receiving TPN containing the amino acid called glutamine. We hope to learn the best composition of TPN so that the body can more efficiently repair wounded tissues and recover earlier from an acute burn injury.

Key facts

Study ID

NCT00216996

Run by

Massachusetts General Hospital

People needed

0

Last updated by the study team

2016-11-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Burn patients being treated at MGH Burn Unit with one or more of the following criteria: 1) >=5% TBSA; 2) inhalation injury; or 3) resting energy expenditure (REE) of >15% of the predicted Basal Metabolic Rate using the Harris-Benedict equation.
• Must be receiving total parenteral nutrition in the course of their treatment.

You may not qualify if…

• Patients with thyroid disease. Patients who are not hemodynamically stable or show unstable vital signs Patients at the stage of major organ failure, e.g. renal and/or liver failure.

Where it is running

• Massachusetts General Hospital Burn Unit — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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