Study of Arginine Metabolism and Nitric Oxide Formation in Relation to Glutamine Supply in Severely Burned Patients

Status unconfirmed · Not applicable

Conditions studied: Burns

In brief

The purpose of the study is to understand the way the body uses amino acids and proteins in burned patient during the time they cannot eat normally. This study aims to understand the metabolism of the amino acid arginine in the body after burn injury. The results of this study will help determine the best composition of food needed during an acute burn injury so that body can more efficiently use the supplied nutrient for optimal burn wound healing and early recovery.

Key facts

Study ID

NCT00216970

Run by

Massachusetts General Hospital

People needed

16

Starts

1997-08-01

Expected to finish

2009-12-01

Last updated by the study team

2009-08-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Burn patients being treated at MGH Burn Unit with one or more of the following criteria: 1) >=5% TBSA; 2) inhalation injury; or 3) resting energy expenditure (REE) of >15% of the predicted Basal Metabolic Rate using the Harris-Benedict equation.
• Must be receiving total parenteral nutrition in the course of their treatment.

You may not qualify if…

• Patients with thyroid disease
• Patients who are not hemodynamically stable or show unstable vital signs
• Patients at the stage of major organ failure, e.g. renal and/or liver failure.

Where it is running

• MGH Burn Unit — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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