Pilot Study to Evaluate Escitalopram in Obsessive-compulsive Disorder

Completed · Phase 2 · Has a placebo group

Conditions studied: OCD

In brief

This study will determine the safety and effectiveness of escitalopram (Lexapro)in treating obsessive-compulsive disorder (OCD) symptoms.

Key facts

Study ID

NCT00215137

Run by

Duke University

People needed

14

Starts

2004-10-01

Expected to finish

2009-03-01

Last updated by the study team

2014-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of OCD
• A minimum score of 16 on the Yale Brown Obsessive-Compulsive Scale (YBOCS) at both the screening and baseline visits

You may not qualify if…

• Lifetime history of psychosis or cognitive dysfunction due to a general medical condition or substance use
• A primary diagnosis of another Axis I psychiatric disorder
• Alcohol or other substance abuse or dependence within the last 6 months
• Unstable medical condition
• Clinically significant laboratory abnormality
• Failure of a previous 10-week trial of citalopram of at least 40 mg/day or escitalopram 20 mg/day
• Active suicidality
• History of violent behavior in the past year or current risk of serious violence
• A history of sensitivity to citalopram or escitalopram
• Use of other investigational drugs within 30 days of baseline or other psychotropic drugs or herbs within 14 days of baseline (28 days for fluoxetine)
• Need for concurrent psychotherapeutic intervention
• Pregnant or lactating females.

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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