Evaluation of Breast Cancer Surgical Margins Using Optical Spectroscopy

Completed · Not applicable

Conditions studied: Breast Cancer

In brief

This study will apply optical spectroscopy to intraoperative margin assessment during surgery for breast cancer. We hypothesize that a combination of fluorescence spectroscopy and diffuse reflectance spectroscopy will reliably detect involved surgical margins. Twenty patients with ductal carcinoma in-situ will undergo a standard lumpectomy followed by scanning with a sterile optical spectroscopy probe. Frozen sections from the surgical cavity will be used to evaluate the margins. Optical spectroscopy data will be categorized as benign or malignant using a statistical algorithm and the results will be compared with the frozen and permanent section results.

Key facts

Study ID

NCT00214292

Run by

University of Wisconsin, Madison

People needed

20

Starts

2005-05-01

Expected to finish

2011-03-01

Last updated by the study team

2016-01-29

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• ductal carcinoma in-situ or invasive carcinoma diagnosed by image directed core biopsy who are planning to undergo breast conserving surgery

You may not qualify if…

• patients who were diagnosed with excisional biopsy and patients undergoing mastectomy

Where it is running

• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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