Spironolactone in Patients With Single Ventricle Heart

Completed · Not applicable

Conditions studied: Congenital Disorders

In brief

Ultrasound is a technique that can provide images of the blood vessels such as arteries. The size of the arteries, such as the main blood vessel in the arm, can change under different conditions. Using ultrasound we can see how arteries change with movement or even drugs. We want to use ultrasound to see how blood vessels look in patients with Congestive Heart Failure (CHF) and to also see how a drug called Spironolactone, commonly prescribed for patients with this disease, effects blood vessel function in patients with congestive heart failure. This information may be used to change the standard of care for patients with heart failure especially if we show that Spironolactone has a positive effect on vessel function in patients with CHF.

Key facts

Study ID

NCT00211081

Run by

Emory University

People needed

12

Starts

2004-11-01

Expected to finish

2008-06-01

Last updated by the study team

2017-11-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Single Ventricle Subjects
• >17 years
• have undergone Fontan Procedure

You may not qualify if…

• History of smoking
• Diabetes mellitus
• Renal failure (serum creatinine > 2.5 mg/dl)
• Recovering spironolactone for maintenance therapy
• History of hyperkalemia (serum potassium> 5.5 mEq/L)

Where it is running

• Emory Clinic — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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