A Study to Provide Access to Trabectedin in Participants With Locally Advanced or Metastatic Soft Tissue Sarcoma Who Have Persistent or Recurrent Disease and Who Are Not Expected to Benefit From Currently Available Standard of Care Treatment

NO_LONGER_AVAILABLE

Conditions studied: Sarcoma

In brief

The purpose of this study is to facilitate access to trabectedin for eligible previously treated patients with soft tissue sarcoma (STS), who cannot be expected to benefit from currently available therapeutic options but who may benefit from treatment with trabectedin. The safety profile of trabectedin will be evaluated to further assess the potential risks of trabectedin treatment.

Key facts

Study ID

NCT00210665

Run by

Janssen Research & Development, LLC

Last updated by the study team

2017-10-10

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unresectable advanced or metastatic histologically proven soft tissue sarcoma (STS). Eligibility will include adult participants with desmoplastic small round cell tumor
• Must have relapsed or had progressive disease following standard of care treatment with chemotherapy prior to enrollment or intolerant to prior standard of care treatment with chemotherapy due to safety issues
• Recovery from toxic effects of prior therapies to Grade 1 or better according to National Cancer Institute-Common Terminology Criteria of Adverse Events (criteria used to grade the severity of toxic effects on a scale from 0 to 5 - Grade 1 = mild in severity, Grade 0 = no severity)
• Clinical test results within acceptable limits (ie, hematologic, clinical chemistry and hepatic function test results)
• Female participants must be postmenopausal, surgically sterile, abstinent, or if sexually active, be practicing 2 effective methods of birth control (eg, prescription hormonal contraceptive, intrauterine device, double-barrier method [eg, condoms, occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam, cream, gel, film, or suppository]), before entry, and must agree to continue to use these same methods of contraception throughout the study and for 3 months thereafter. Male participants must agree to use an adequate contraception method as deemed appropriate by the investigator (eg, vasectomy, double-barrier, partner using effective contraception) and to not donate sperm for a minimum of 5 months after treatment discontinuation

You may not qualify if…

• Diagnosis of Ewing's sarcoma or osteosarcoma, less than 3 weeks from last dose of radiation, systemic cytotoxic therapy (or 4 half lives, whichever is longer)
• Active symptomatic viral hepatitis or chronic liver disease
• Significant uncontrolled cardiac condition, including New York Heart Association Class II or greater heart failure, uncontrolled angina pectoris, myocardial infarction within 6 months before enrollment, significant pericardial disease, or uncontrolled or arrhythmias
• Active infection
• Female participant who is pregnant or breastfeeding

Where it is running

• Study site — Anchorage, Alaska, United States
• Study site — San Diego, California, United States
• Study site — Santa Monica, California, United States
• Study site — Aurora, Colorado, United States
• Study site — Daytona Beach, Florida, United States
• Study site — Hollywood, Florida, United States
• Study site — Atlanta, Georgia, United States
• Study site — Coeur d'Alene, Idaho, United States
• Study site — Park Ridge, Illinois, United States
• Study site — Iowa City, Iowa, United States
• Study site — Overland Park, Kansas, United States
• Study site — Louisville, Kentucky, United States
• Study site — Metairie, Louisiana, United States
• Study site — Baltimore, Maryland, United States
• Study site — Boston, Massachusetts, United States
• Study site — Ann Arbor, Michigan, United States
• Study site — Detroit, Michigan, United States
• Study site — Rochester, Minnesota, United States
• Study site — Saint Joseph, Missouri, United States
• Study site — Omaha, Nebraska, United States
• Study site — Newark, New Jersey, United States
• Study site — New York, New York, United States
• Study site — Cleveland, Ohio, United States
• Study site — Tulsa, Oklahoma, United States
• Study site — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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