Treatment of Reduced Heart Rate Variability Associated With Major Depression With Electroconvulsive Therapy
Completed
Conditions studied: Major Depressive Disorder
In brief
The purpose of this study is to evaluate alterations in sympathetic tone in patients with major depression with and without ischemic heart disease and then to reevaluate these patients after 8 treatments with electroconvulsive therapy(ECT). We expect to support the hypothesis that HRV are pathophysiologically associated with the state of major depression. We hypothesize the following: 1. Heart rate variability (HRV) will be decreased prior to treatment of depression in comparison to post-treatment measures of HRV. 2. After 8 treatments with ECT, HRV will be increased under basal conditions.
Key facts
- Study ID
- NCT00209066
- Run by
- Emory University
- People needed
- 50
- Starts
- 1998-11-01
- Expected to finish
- 2005-04-01
- Last updated by the study team
- 2013-11-19
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Patients will not be accepted into the study if they abuse alcohol or drugs.
- Patients will be excluded from the study if they have had an MI within the past three months, unstable crescendo angina or ongoing warfarin treatment
- Patients also will not be accepted into the study if ECT will be harmful to them. These patients include:
- those who have had a recent MI (<3 months)
- those who have an infection of the brain,
- those who have a condition in which there is increased intracranial pressure (e.g. a brain tumor)
- those who cannot tolerate general anesthesia.
- Any patient with a current DSM-IV Axis I diagnosis other than major depression will be excluded from the study.
Where it is running
- Emory University School of Medicine — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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