A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving

Completed · Phase 2

Conditions studied: Tobacco Use Disorder

In brief

The purpose of this study is to gather pilot data to determine feasibility of and guide the development of a larger clinical trial investigating the effects of topiramate as an adjunct to nicotine replacement therapy and behavioral counseling in smoking cessation treatment. It is hypothesized that topiramate will decrease nicotine craving and result in improved outcomes for smoking cessation.

Key facts

Study ID

NCT00208858

Run by

Emory University

Starts

2004-12-01

Expected to finish

2006-12-01

Last updated by the study team

2014-06-16

Who can join

Age: 18 and older, up to 55. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male, between ages of 18-55
• Meets DSM-IV criteria for nicotine dependence
• Smoke at least 20 cigarettes per day
• Motivated to quit smoking

You may not qualify if…

• Serious or unstable medical conditions
• Current psychiatric disorder requiring medication or treatment
• Taking medication that create risk of interaction with study drug
• Current participation in another smoking cessation treatment

Where it is running

• Atlanta VA Medical Center — Decatur, Georgia, United States

Full record on ClinicalTrials.gov

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