Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia

Completed · Phase 4

Conditions studied: Schizophrenia, Schizoaffective Disorder, Substance Abuse, Substance Dependence

In brief

It is hypothesized that the atypical antipsychotic, Seroquel, will cause significant reduction in drug and alcohol cravings in patients with schizophrenia and comorbid cocaine and/methamphetamine dependence compared to the atypical antipsychotic, risperidone (Risperdal). Patients treated with Seroquel will have less use of cocaine and/or methamphetamine as measured by the Time Line Follow-back, over a 24-week follow-up period.

Key facts

Study ID

NCT00208143

Run by

Creighton University

People needed

20

Starts

2003-11-01

Expected to finish

2005-12-01

Last updated by the study team

2007-12-13

Who can join

Age: 19 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 19 - 65.
• Diagnosis of schizophrenia or schizoaffective disorder with comorbid cocaine and/or amphetamine abuse/dependence as confirmed by Structured Clinical Interview for DSM-IV.
• Comorbid diagnoses of depression, anxiety and/or personality disorders are permitted.
• Ability to provide signed informed consent.
• Stable general medical health.

You may not qualify if…

• Dangerous to self or others.
• Pregnancy, inability or unwillingness to use approved methods of birth control.
• Inability or unwillingness to provide signed informed consent.
• Diagnosis of bipolar disorder, primary major depressive disorder (As major Axis I diagnosis).
• Inability to attend outpatient research clinic.
• Medical conditions, which would preclude use of Seroquel.
• Absolute need for ongoing treatment with antipsychotic other than Seroquel.
• Medical instability defined as likelihood of needing to change prescription medication during the course of the study.
• Patients currently taking quetiapine or risperidone.
• Patients with unsuccessful treatment with quetiapine or risperidone.
• Subjects with a HAM-D score of ≥20 at screening.

Where it is running

• Creighton University Psychiatry and Research Center — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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