A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease

Stopped early · Phase 1 · Has a placebo group

Conditions studied: Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)

In brief

The purpose of this study is to examine the relationship between depressive symptoms and markers of inflammation, two predictors of heart disease.

Key facts

Study ID

NCT00208117

Run by

New York State Psychiatric Institute

People needed

7

Starts

2005-04-01

Expected to finish

2009-01-01

Last updated by the study team

2012-05-31

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 - 60
• Mild depression
• Inflammatory markers: CRP > 2

You may not qualify if…

• Non-English or Non-Spanish speakers
• Active suicidal or homicidal ideation
• Current alcohol or other substance abuse
• Psychotic features
• Current personality disorder
• History of bipolar depressive disorder
• Any current psychotic disorder
• Current major depressive disorder
• Current depression treatment or treatment within preceding 6 weeks
• History of chronic liver and/or renal disease
• Current use or contraindication to any of the tested medications
• Absence of a response to a previous adequate trial of any of the tested medications
• Pregnant or lactating women
• History of coronary artery disease
• Current use of statins
• Current, regular aspirin use
• Antibiotic use within the previous four weeks
• History of diabetes
• Inflammatory diseases
• Meets NCEP guidelines for cholesterol lowering therapy

Where it is running

• Columbia University Department of General Medicine — New York, New York, United States

Full record on ClinicalTrials.gov

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