Test-Retest Reliability of Pulmonary Function Tests in Patients With Duchenne's Muscular Dystrophy

Withdrawn before enrolling

Conditions studied: Duchenne's Muscular Dystrophy, Scoliosis

In brief

Nearly all patients with Duchenne's Muscular Dystrophy (DMD) have scoliosis. Posterior instrumented spinal fusion, which is a surgery to correct scoliosis, has been shown to improve quality of life and satisfaction of both parents and families. The progressive muscular weakness leads to the development of scoliosis soon after the child has become unable to walk. The muscular weakness and scoliosis also affect the pulmonary function of these children. Pulmonary Function Tests (PFT) have been used to determine "pulmonary fitness" prior to surgery as a way to determine how well or if the child will tolerate surgery. Children with poor results on the PFT are determined to be too fragile to tolerate such a large operation. The physicians conducting this study feel that the PFT may be inaccurate and that this may not be the best single test to determine "pulmonary fitness". The physicians conducting the study think things like the time of day the study is done, how tired you are when you complete the test, and how well you understand the test may affect the results of the test.

Key facts

Study ID

NCT00207857

Run by

Children's Healthcare of Atlanta

People needed

0

Starts

2004-03-01

Expected to finish

2005-08-01

Last updated by the study team

2015-02-04

Who can join

Age: 6 and older, up to 21. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male
• Duchenne's Muscular Dystrophy with diagnosed confirmed by a neurologist
• No longer able to ambulate for any meaningful amount of time
• No previous spinal operation

You may not qualify if…

• Any other type of muscular dystrophy or spinal muscular atrophy
• Tracheotomy
• Contractures of the upper extremities that would preclude using arm span as an estimation for height
• Previous spinal surgery
• Asthma, recurrent pneumonia, or other chronic lung disease

Where it is running

• Children's Healthcare of Atlanta @ Scottish Rite — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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