Ventricular-Vascular Coupling in Heart Failure
Completed
Conditions studied: Heart Failure With Preserved Ejection Fraction
In brief
This study will test the hypothesis that increases in ventricular-vascular stiffness can be demonstrated by arterial tonometry and echocardiography in subjects with heart failure with preserved ejection fraction (HF-nlEF)(i.e. normal left ventricular function.) We will also track changes in pulsatile hemodynamics over time in subjects hospitalized with HF-nlEF.
Key facts
- Study ID
- NCT00207220
- Run by
- Brigham and Women's Hospital
- People needed
- 53
- Starts
- 2004-01-01
- Expected to finish
- 2007-01-01
- Last updated by the study team
- 2007-11-09
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects with heart failure and preserved ejection fraction
- clinical signs of heart failure
- serum brain natriuretic peptide (BNP) >100pg/mL
- NYHA functional class II-IV
- left ventricular ejection fraction(LVEF) >=50% measured by echocardiography
- Non-diabetic subjects with hypertension
- treated or untreated essential hypertension
- LVEF >=50% measured by echocardiography
- Diabetic subjects with hypertension
- Type 2 diabetes
- treated or untreated essential hypertension
- LVEF >=50% measured by echocardiography
- Normotensive control subjects
- normal blood pressure (i.e. < 140/90 mmHg)
- LVEF >=50% measured by echocardiography
You may not qualify if…
- Subjects with heart failure and preserved ejection fraction
- atrial fibrillation
- symptoms of angina or a myocardial infarction (MI) within 6 months
- known significant coronary artery disease (CAD) (stenosis > 70%)
- significant valvular heart disease
- restrictive/constrictive heart disease
- inability to lie flat for procedure (estimated duration 1 hour)
- Non-diabetic subjects with hypertension
- atrial fibrillation
- symptoms of angina or a myocardial infarction (MI) within 6 months
- known significant coronary artery disease (CAD) (stenosis > 70%)
- significant valvular heart disease
- restrictive/constrictive heart disease
- inability to lie flat for procedure (estimated duration 1 hour)
- prior history of heart failure or unexplained dyspnea
- Diabetic subjects with hypertension
- atrial fibrillation
- symptoms of angina or a myocardial infarction (MI) within 6 months
- known significant coronary artery disease (CAD) (stenosis > 70%)
- significant valvular heart disease
- restrictive/constrictive heart disease
- inability to lie flat for procedure (estimated duration 1 hour)
- prior history of heart failure or unexplained dyspnea
- Normotensive control subjects
- prior history of structural heart disease or ventricular hypertrophy
Where it is running
- Brigham & Women's Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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