A Study of the Cataractogenic Potential of Seroquel and Risperdal in the Treatment of Participants With Schizophrenia or Schizoaffective Disorder

Completed · Phase 4

Conditions studied: Schizophrenia, Schizoaffective Disorder

In brief

This Phase IV, randomized, parallel-group study is designed to evaluate the cataractogenic potential of quetiapine fumarate (SEROQUEL) compared with that of a putative non-cataractogenic antipsychotic medication risperidone (RISPERDAL). This study is being conducted to fulfill the SEROQUEL Phase IV commitment regarding evaluation of cataractogenic potential.

Key facts

Study ID

NCT00206102

Run by

AstraZeneca

People needed

1098

Starts

2003-09-01

Expected to finish

2008-10-01

Last updated by the study team

2013-01-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women age 18 to 65
• Both Eyes present with lenses intact (no previous cataract extractions)
• Stable place of residency

You may not qualify if…

• History of corneal surgery
• Legal blindness (defined as best corrected visual acuity of 20/200 or worse in one or both eyes
• Previous participation in this study

Where it is running

• Research Site — Mabelvale, Arkansas, United States
• Research Site — Morrilton, Arkansas, United States
• Research Site — Anaheim, California, United States
• Research Site — Cerritos, California, United States
• Research Site — Chula Vista, California, United States
• Research Site — Garden Grove, California, United States
• Research Site — Long Beach, California, United States
• Research Site — Los Angeles, California, United States
• Research Site — Orange, California, United States
• Research Site — San Diego, California, United States
• Research Site — San Marcos, California, United States
• Research Site — Denver, Colorado, United States
• Research Site — New Britian, Connecticut, United States
• Research Site — Boca Raton, Florida, United States
• Research Site — Boynton Beach, Florida, United States
• Research Site — Deerfield Beach, Florida, United States
• Research Site — Fort Lauderdale, Florida, United States
• Research Site — Orlando, Florida, United States
• Research Site — Pompano Beach, Florida, United States
• Research Site — Tampa, Florida, United States
• Research Site — West Palm Beach, Florida, United States
• Research Site — Atlanta, Georgia, United States
• Research Site — Augusta, Georgia, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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