The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity

Completed · Phase 1 · Has a placebo group

Conditions studied: Major Depressive Disorder

In brief

The purpose of the study is to evaluate the effects of a single-dose of Wellbutrin XL (bupropion hydrochloride) on reward processing.

Key facts

Study ID: NCT00205946
Run by: Affective Neuroscience Laboratory
People needed: 32
Starts: 2005-04-01
Expected to finish: 2007-07-01
Last updated by the study team: 2007-12-06

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse)
Non-Smoker
Right-handed (Chapman and Chapman 1987)
Ability to provide informed consent

You may not qualify if…

Predisposition to seizure (e.g. family history of a seizure disorder, history of head trauma) or current use of medications that lower the seizure threshold
History or current diagnosis of anorexia or bulimia
Alcohol or substance abuse within the past year
Current usage of Wellbutrin or Zyban or other drugs that contain bupropion
Recent discontinuation of alcohol or sedatives (including benzodiazepines)
Use of (in the last 2 weeks) medications that may have antidepressant properties (ex. some herbal supplements)
Known allergies to bupropion
Currently lactating, pregnant or believe you are likely to be pregnant (enrolled subjects who are not using reliable contraception and have engaged in sexual intercourse since their last menstrual period will be given a self-administered pregnancy test.)
Left-handed/ambidextrous
Evidence of neurological illness
Serious suicide or homicide risk
Concomitant medications other than those listed in the exclusion criteria will be considered on an individual basis. Oral contraceptives will be allowed.

Where it is running

The Depression Clinical and Research Program, Massachusetts General Hospital — Boston, Massachusetts, United States
Affective Neuroscience Laboratory, Department of Psychology, Harvard University — Cambridge, Massachusetts, United States

Full record on ClinicalTrials.gov

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