Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated Patients

Completed

Conditions studied: Intubation, Critically Ill

In brief

This study will examine the impact of acute illness on sequential airway IgA levels in intensive care patients who will require prolonged intubation. Infections are the most common cause of late deaths in non-head injured trauma patients and a frequent cause of morbidity and mortality in hospitalized patients, especially intubated Intensive Care Unit (ICU) patients. Nosocomial pneumonia is the most common of these infections, and its incidence in defined populations of critically injured patients is responsive to route and type of nutrition. This study will focus on the mechanisms of specific immune mucosal defenses in intestinal and extraintestinal sites and link enteral feeding (or lack of it) with maintenance (or deterioration) of respiratory mucosal defenses.

Key facts

Study ID

NCT00205309

Run by

University of Wisconsin, Madison

People needed

13

Starts

2003-01-01

Expected to finish

2011-06-01

Last updated by the study team

2012-10-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must be intubated, intensive care patients.

You may not qualify if…

• No severe pulmonary contusions or evidence of airway bleeding

Where it is running

• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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