Catheterization Laboratory Study: Acute Responses in Diastolic Heart Failure

Completed · Not applicable

Conditions studied: Heart Failure, Congestive

In brief

1. Research question: What is the response of the heart's pumping function to changes in heart chamber pressures? 2. Experimental design: Patients undergoing routine cardiac catheterization will be studied. A thermodilution pulmonary artery catheter will be inserted through a venous sheath and threaded into the pulmonary artery. After several minutes of quiet rest, baseline hemodynamics will be obtained, including a determination of cardiac output using thermodilution techniques and 30 seconds of pressure recordings from the left ventricle and proximal aorta. In addition, a brief echocardiogram will be performed, to determine ejection fraction and indices of diastolic filling. Finally, arterial tonometry will be obtained in quick succession from the brachial, radial, femoral, and carotid arteries. Following the collection of baseline data, a bolus and infusion of nesiritide will be started. After 10 minutes of nesiritide infusion, with the drug still infusing, a full set of invasive hemodynamics will again be obtained, as well as brief echocardiographic and arterial tonometry examinations.

Key facts

Study ID

NCT00204945

Run by

University of Wisconsin, Madison

People needed

15

Starts

2005-02-01

Expected to finish

2007-06-20

Last updated by the study team

2019-02-08

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cardiac catheterization

You may not qualify if…

• Unstable coronary syndrome,
• Critical coronary stenoses (>90%),
• Severe peripheral vascular disease,
• Symptomatic hypotension at completion of routine diagnostic cath,
• Significant valvular disease, resting heart rate >120 beats/min,
• Ejection fraction <45%,
• Presence of contraindications to nesiritide administration,
• Any evidence of clinical instability.

Where it is running

• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.