The Role of GER in Exercise Triggered Asthma

Completed · Phase 2/Phase 3

Conditions studied: Asthma

In brief

HYPOTHESIS Gastroesophageal reflux is a major contributor to exercise-triggered asthma. Two groups of patients will be studied: those with asthma who have difficulty with exertion, those without asthma who experience difficulty with exertion. Both groups will experience gastroesophageal reflux (GER) twice of less per week. Patients will complete a treadmill exam to determine their VO2 max. They will then undergo pH monitoring while exercising for 30 minutes at 65-70% of their VO2 max. Subjects will be given placebo or acid suppression pill for 12 weeks. At the end of 12 weeks, the subjects will repeat the exercise (30 minutes) and 24-hour pH study.

Key facts

Study ID

NCT00204672

Run by

University of Utah

People needed

36

Starts

2000-10-01

Expected to finish

2005-09-01

Last updated by the study team

2005-09-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Exercise-triggered asthmatics - defined as asthmatics with exertion as their primary exacerbating factor and experiencing less than two episodes of classic gastroesophageal reflux a week.

You may not qualify if…

• Exclusion criteria will be the following:
• Severe asthma (recent or repeated hospitalizations)
• Severe angina, cardiac arrhythmia's, heart failure, prior MI
• Respiratory illness e.g. COPD
• Inability to receive therapy/pH probe
• Pregnancy
• Minors, prisoners, individuals unable to give informed consent
• Prior upper GI surgery (gastrectomy, etc)

Where it is running

• University of Utah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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