TNF-Alpha Inhibition for Treatment of Alzheimer's Disease

Completed · Phase 1

Conditions studied: Alzheimer's Disease

In brief

It is widely believed that inflammation contributes to the pathogenesis of AD. TNF has been implicated in both AD and neurological inflammation. Anti-TNF therapy is therefore surmised to be of potential benefit for treating AD.

Key facts

Study ID

NCT00203359

Run by

Tobinick, Edward Lewis, M.D.

People needed

15

Starts

2004-09-01

Expected to finish

2006-04-01

Last updated by the study team

2006-04-24

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• NINCDS-ADRDA Criteria for Alzheimer's disease
• CT or MRI consistent with AD

You may not qualify if…

• active infection
• CHF
• demyelinating disease
• uncontrolled diabetes mellitus
• vascular dementia
• clinically significant neurologic disease other than AD
• Hachinski >4
• history of lymphoma
• TBC
• wbc<2500
• platelets<100,000
• HCT<30
• pregnancy
• premenopausal, fertile not on acceptable birth control
• change in neuroactive medication within 4 weeks of study initiation

Where it is running

• Edward Tobinick, MD (private medical office) — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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