Perioperative Effect of Atenolol on Cytokine Profiles

Status unconfirmed · Phase 4 · Has a placebo group

Conditions studied: Surgery

In brief

Studies have shown that beta-blockers such as atenolol when given in the perioperative period reduce morbidity and mortality. One study showed that atenolol given just during the surgery period, seemed to improve outcomes up to 2 years later. This is hard to explain since beta-blockers act on the body by blocking the effects of adrenalin and thereby lowering heart rate and blood pressure. This study is designed to find out if perioperative atenolol might exert its long term effects through an anti-inflammatory mechanism rather than by lowering heart rate and blood pressure. It is known that inflammation increases after surgery as part of the healing process. However, it is also becoming clear that low-grade chronic inflammation can also lead to long term adverse effects.

Key facts

Study ID

NCT00202358

Run by

Saini Foundation

People needed

60

Starts

2002-11-01

Expected to finish

2008-09-01

Last updated by the study team

2008-06-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• elective abdominal, orthopedic, or gynecologic surgery
• ability to give informed consent
• ability to tolerate beta-blocker therapy
• ability to comply with follow-up requirements

You may not qualify if…

• currently receiving beta-blocker therapy
• EKG documented 2nd or 3rd degree heart block
• EKG documented sinus bradycardia
• Serum creatinine > 2.0
• current treatment asthma
• history of rheumatoid arthritis
• history of Crohn's disease
• history of lupus
• history of inflammatory cancer

Where it is running

• Cape Cod Hospital — Hyannis, Massachusetts, United States

Full record on ClinicalTrials.gov

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