Expression of Tuberculosis in the Lung

Completed

Conditions studied: Tuberculosis

In brief

The purpose of this study is to assess lung immune responses in patients with active pulmonary tuberculosis (TB) and in healthy control persons who are exposed to Mycobacterium tuberculosis in households of patients with TB or who are unexposed.

Key facts

Study ID

NCT00201253

Run by

University of Medicine and Dentistry of New Jersey

People needed

40

Starts

2000-09-01

Expected to finish

2008-06-01

Last updated by the study team

2015-01-26

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• TB patients who are 18 to 65 years old
• Clinical and radiographic signs and symptoms consistent with pulmonary TB
• Start date of antituberculous chemotherapy less than 10 days prior to procedures
• Sputum smear positive for acid fast bacilli
• Drug-sensitive, culture-confirmed growth of M. tuberculosis from sputum
• Willing to provide informed consent for participation in bronchoalveolar lavage and venipuncture studies

You may not qualify if…

• TB patients who have HIV-1 coinfection
• History of any chronic medical condition requiring daily medication (including diabetes mellitus, hypertension, chronic infections, renal or cardiac failure, and peptic ulcer disease)
• History of asthma or upper or lower respiratory tract infection within 2 months of the study
• Hemoglobin level less than 10g/dl

Where it is running

• UMDNJ-New Jersey Medical School — Newark, New Jersey, United States
• Instituto Nacional de Enfermedades Respiratorias (INER) — Mexico City, Mexico

Full record on ClinicalTrials.gov

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