Effects of Anticipation of Pain Relief on Brain Mechanisms

Completed · Not applicable

Conditions studied: Pain

In brief

This study will use brain imaging technology to examine chemical systems in the brain that suppress pain and stress when an individual has an expectation of pain relief.

Key facts

Study ID

NCT00200876

Run by

University of Michigan

People needed

60

Starts

2003-09-01

Expected to finish

2008-06-01

Last updated by the study team

2017-03-24

Who can join

Age: 20 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Willing and able to comply with all study requirements

You may not qualify if…

• Presence of pain at study entry
• Personal or first-degree (e.g., mother, father, sister, brother) family history of neurologic or psychiatric disorders
• History of substance abuse or dependence
• Left-handed or ambidextrous
• Positive urine toxicology screen
• Acute or uncorrected medical illness that may interfere with the study
• Unable to tolerate brain scanning procedures
• Current treatment with antipsychotics, mood stabilizers, isoniazid (a drug for tuberculosis [TB]), glucocorticoids/mineralocorticoids, psychostimulant appetite suppressants, or centrally active antihypertensive drugs
• Treatment with hormones, antidepressants, or opioids within 6 months prior to study entry
• Treatment with sedative hypnotic medications or over-the-counter sleeping aids within 1 month prior to study entry
• Diagnosis of depression
• Competitive exercise, or exercise exceeding 1 hour each day
• Regular smoking within 5 years prior to study entry

Where it is running

• University of Michigan Medical Center — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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