Effectiveness of a Low Carbohydrate Diet Versus a High Carbohydrate Diet in Promoting Weight Loss and Improved Health

Completed · Phase 2

Conditions studied: Obesity, Hypertension

In brief

This study will examine the effects of a low carbohydrate diet versus a high carbohydrate diet on weight loss.

Key facts

Study ID

NCT00200720

Run by

Kaiser Permanente

People needed

260

Starts

2005-04-01

Expected to finish

2010-06-01

Last updated by the study team

2012-12-06

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Body mass index (BMI) of 27 to 50
• Fasting glucose less than 126 mg/dl
• Total fasting cholesterol less than 260 mg/dl
• Total fasting triglycerides less than 400 mg/dl
• Permission of primary care provider to participate in the study
• Normal liver and kidney function
• Willing to modify diet and other health behaviors
• Willing to use an acceptable method of contraception for the duration of the study

You may not qualify if…

• Any medical condition that may make weight loss medically inadvisable
• Weigh more than 400 lbs
• History of kidney failure
• Current use of more than 3 blood pressure medications
• Change in blood pressure medications within 3 months prior to study entry
• Diagnosis of cardiovascular disease within 6 months prior to study entry
• Cancer diagnosis within 2 years of study entry. Participants with basal cell skin cancer are not excluded.
• History of psychiatric hospitalization within 2 years prior to study entry
• Consumption of more than three alcoholic drinks a day
• Type I or II diabetes
• Current use of hypolipidemics, antipsychotics, hypoglycemics, glucocorticoids, or thyroid medication
• Plan to move during study
• Current participation in another clinical trial
• Pregnancy or breastfeeding

Where it is running

• Kaiser Permanente Center for Health Research — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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