Both Exercise and Adenosine Stress Testing

Stopped early · Phase 4

Conditions studied: Coronary Artery Disease

In brief

The purpose of this study is to compare the 2-year cardiac outcomes for women with limited exercise capability based on the resuls of either pharmacological stress myocardial perfusion imaging or a combined protocol that incorporates both exercise and pharmacological stress. The goal of the study is to compare these two methods for patient tolerability, safety and prognostic value

Key facts

Study ID

NCT00200629

Run by

Midwest Heart Foundation

People needed

200

Starts

2005-06-01

Last updated by the study team

2011-08-09

Who can join

Age: 60 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female
• Age greater to or equal to 60 years old
• Must present with chest pain, fatigue, or other anginal equivalent symptoms
• Must be referred for stress testing based on clinical indications
• Must be able to provide written informed consent

You may not qualify if…

• Women with known coronary artery disease (>50% lesion OR prior MI OR prior revascularization)
• Inability to perform any exercise on a treadmill
• Nuclear medicine study within the preceding 30 days
• Contraindication to adenosine, including moderate to severe COPD or asthma, second or third degree AV block, or known hypersensitivity to adenosine or aminophylline
• Left bundle branch block or electronic ventricular pacemaker
• Significant valvular heart disease
• Hemodynamic instability (blood pressure >210/110 ml/Hg or <90/60 mm/Hg)
• 2° or 3° atrioventricular block
• Symptomatic heart failure
• Ingestion of theophylline or dipyridamole within the preceding 48 hours
• Unavailability for follow-up

Where it is running

• Southwest Heart — Tucson, Arizona, United States
• Sutter Roseville Medical Center — Roseville, California, United States
• Sacramento Heart & Vascular Research Center — Sacramento, California, United States
• Delaware SPECT Imaging — Newark, Delaware, United States
• Diagnostic Cardiology, PA — Jacksonville, Florida, United States
• Jacksonville Heart Center, PA — Jacksonville Beach, Florida, United States
• Cardiac Disease Specialists — Atlanta, Georgia, United States
• Idaho Cardiology Associates — Boise, Idaho, United States
• Idaho Cardiology Associates — Meridian, Idaho, United States
• North Shore Cardiology — Bannockburn, Illinois, United States
• Iowa Heart Center — Des Moines, Iowa, United States
• Androscoggin Cardiology Associates — Auburn, Maine, United States
• Cardiovascular Consultants of Maine, PA — Scarborough, Maine, United States
• Albany Associates in Cardiology — Albany, New York, United States
• Mid-Valley Cardiology — Kingston, New York, United States
• North Shore University Hospital — Manhasset, New York, United States
• Cardiology Consultants of Philadelphia — Philadelphia, Pennsylvania, United States
• Cardiology Consultants of Philadelphia — Philadelphia, Pennsylvania, United States
• Medical University of SC — Charleston, South Carolina, United States
• Deaconess Medical Center — Spokane, Washington, United States

Full record on ClinicalTrials.gov

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