Assessment of Early Genetic Changes in Smokers

Stopped early

Conditions studied: Cancer of Head and Neck, Smoking

In brief

This study will look at the genetic profile of cells taken from the oral cavity of healthy college students who smoke and who do not smoke cigarettes. This will be done using a small brush similar to that used in Pap tests for cervical cancer detection. Our aim is to determine if smoking causes early genetic changes in the DNA of these cells such as have been seen in the cells of cancerous tumors of the head and neck area and nearby healthy tissues. This will be correlated with data from subject questionnaires to assess tobacco use, and other behavior and demographic information.

Key facts

Study ID

NCT00200408

Run by

Montefiore Medical Center

People needed

10

Starts

2004-03-01

Last updated by the study team

2015-04-08

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• College freshmen and sophomores
• Smokers must be between the ages of 18 and 25
• Smokers must have smoked regularly for at least 2 years and be currently smoking
• Smokers must intend to stay in the New York area for at least 3 years.
• Non-smokers must be non-users of marijuana -

You may not qualify if…

• Current HIV/AIDS infection
• Use of chewing tobacco

Where it is running

• Montefiore Medical Center — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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