An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study

Completed · Not applicable

Conditions studied: Carpometacarpal Osteoarthritis

In brief

The purpose of this study is to find out if hyaluronan, an injectable medication for knee arthritis, also works for arthritis at the base of the thumb. This study will also evaluate how good ultrasound is at visualizing medication in the thumb joint. We are no longer recruiting for this part of the open label trial.

Key facts

Study ID

NCT00198029

Run by

Hospital for Special Surgery, New York

People needed

32

Starts

2004-10-01

Expected to finish

2009-12-01

Last updated by the study team

2017-04-17

Who can join

Age: 45 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Radiographic evidence of at least moderate narrowing (joint space < 1mm) or the presence of osteophytes or sclerosis at the Carpometacarpal joint
• Patient complaint of unacceptable pain despite modification of activity, a trial of splinting and a therapeutic dose of NSAIDS
• If bilateral disease, only the most severely involved hand, (as defined by VAS for pain), will be entered in the study.
• Proficiency in English.

You may not qualify if…

• Previous bad injury to the thumb
• Previous hand surgery on the study thumb
• Known hand comorbidities (i.e. carpal tunnel syndrome, de Quervains Tenosynovitis etc)
• Rheumatoid arthritis or lupus
• Bleeding problems
• Being on blood thinners (except aspirin)
• Known allergies to any of the medications being used
• Allergies to chicken products
• Current use of oral steroids
• Cancer that is not cured or in remission
• Severe diabetes
• A serious infection somewhere else in the subject's body

Where it is running

• Hospital for Special Surgery — New York, New York, United States

Full record on ClinicalTrials.gov

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