Safety and Efficacy Study of Hydromorphone and Morphine

Completed · Phase 2

Conditions studied: Pain

In brief

To compare a standard weight-based dose of intravenous (IV) hydromorphone (Dilaudid) to a standard weight-based dose of IV morphine in adults presenting to the Emergency Department (ED) with acute severe pain.

Key facts

Study ID

NCT00195910

Run by

Montefiore Medical Center

People needed

198

Starts

2004-10-01

Expected to finish

2005-01-01

Last updated by the study team

2018-08-15

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• adults between the ages of 21 and 65 who presented to the ED with acute pain (defined as pain less than 7 days in duration) (23) of sufficient severity in the judgment of the ED attending to warrant use of IV opioids.

You may not qualify if…

• previous allergy to morphine or hydromorphone
• systolic blood pressure less than 90 mmHg
• alcohol intoxication as judged by the attending physician
• use of other opioids within the past 7 days
• use of an Monoamine Oxidase (MAO) inhibitor
• chronic pain syndromes (such as sickle cell disease or fibromyalgia)

Where it is running

• Montefiore Medical Center — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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