A Trial of Antenatal Treatment of Alloimmune Thrombocytopenia

Completed · Phase 2/Phase 3

Conditions studied: Alloimmune Thrombocytopenia, Fetal Alloimmune Thrombocytopenia

In brief

The purposes of this study are to provide medical management by giving treatment to the mother that will bring up the fetal platelet count and to minimize the number of invasive procedures to the fetus (which may result in serious fetal injuries).

Key facts

Study ID

NCT00194987

Run by

Weill Medical College of Cornell University

People needed

102

Starts

2001-04-01

Expected to finish

2015-06-30

Last updated by the study team

2018-11-07

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Pregnant women are eligible for inclusion into the Very High Risk Group if they:
• are PLA-1 (platelet antigen A1) negative and have known platelet incompatibility with their fetus
• have had a previous child who suffered an antenatal hemorrhage prior to 28 weeks gestation (as best as could be estimated)
• are less than 19 weeks gestation
• Pregnant women are eligible for inclusion into the High Risk Group if they:
• are PLA-1 negative and have known platelet incompatibility with the fetus
• have had a previous child who suffered an antenatal hemorrhage after 28 weeks gestation (as best as could be estimated)
• are between 12-30 weeks gestation
• Pregnant women are eligible for inclusion into the Standard Risk Group if they:
• are PLA-1 negative and have known platelet incompatibility with the fetus
• have not had a previous child who suffered an antenatal hemorrhage
• are between 20-30 weeks gestation

You may not qualify if…

• Women are not eligible for inclusion into the Very High Risk Group if they:
• have had a previous child who suffered an antenatal hemorrhage after 28 weeks gestation
• are greater than 19 weeks gestation
• Women are not eligible for inclusion into the High Risk Group if they:
• have had a previous child who suffered an antenatal hemorrhage prior to 28 weeks gestation
• are greater than 30 weeks gestation
• Women are not eligible for inclusion into the Standard Risk Group if they:
• have had a previous child who suffered an antenatal hemorrhage
• are greater than 30 weeks gestation

Where it is running

• New York Presbyterian Hospital-Weill Cornell Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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