Preferred Treatment of Type 1.5 Diabetes

Completed · Not applicable

Conditions studied: Type 2 Diabetes Mellitus

In brief

The purpose of this research was to test whether one treatment was superior over another in the management of type 1.5 diabetes. Specifically we tested recently diagnosed antibody positive type 2 diabetic patients to determine whether treatment with rosiglitazone results in greater preservation of beta cell function compared to treatment with glyburide.

Key facts

Study ID

NCT00194896

Run by

University of Washington

People needed

64

Starts

2000-02-01

Expected to finish

2008-12-01

Last updated by the study team

2018-03-29

Who can join

Age: 35 and older, up to 69. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age at onset of diabetes - 35-69 years old.
• No history of ketonuria or ketoacidosis.
• Not requiring insulin to achieve glycemic control.
• Not receiving more than two oral hypoglycemic agents.
• Not taking a thiazolidinedione agent.
• HbA1c in established patients (on an oral hypoglycemia agent for over 4 months) of greater than 6% and under 10%.
• Fasting c-peptide greater than or equal to 0.8 ng/ml.
• Women must be either post-menopausal or on adequate birth control (i.e. oral contraceptives, tubal ligation, hysterectomy, condoms, or diaphragm) or use abstinence.

You may not qualify if…

• Patients with history of chronic pancreatitis or other secondary causes of diabetes.
• Patients receiving systemic corticosteroids.
• Patients with severe systemic illness (e.g. recent MI, CHF or cerebral vascular disease).
• Creatinine greater than 1.4 or liver enzymes greater than 2 times the upper limits of normal.
• Not able to adhere to the protocol.

Where it is running

• DVA Puget Sound Health Care System — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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