Effect of Cytokines on Growth of Children With Chronic Kidney Failure

Paused · Phase 4

Conditions studied: Chronic Renal Insufficiency

In brief

Children with chronic kidney failure often do not grow well. This study examines the possible causes of growth failure in these children and the response to recombinant human growth hormone. The growth hormone-insulin-like growth factor axis will be studied in relation to biochemical and immunological parameters as well as body compositional changes pre- and post recombinant human growth hormone therapy.

Key facts

Study ID

NCT00194883

Run by

Weill Medical College of Cornell University

People needed

50

Starts

1997-04-01

Expected to finish

2003-05-01

Last updated by the study team

2017-11-21

Who can join

Age: 1 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current height < 2SD (or < 3rd percentile) for chronological age
• Chronic renal failure (estimated creatinine clearance <75 mL/min/1.73m2) or ESRD (as defined by receiving maintenance HD or PD)
• Age < 21 years and /or growth potential demonstrable by bone age

You may not qualify if…

• Unable or unwilling to adhere to the protocol
• Additional diagnoses that could impair responsiveness to GH, e.g. dwarfism syndromes, significant extra-renal organ disease, e.g. chronic liver disease, or chronic corticosteroid therapy

Where it is running

• Weill Medical College of Cornell University — New York, New York, United States

Full record on ClinicalTrials.gov

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