Cefpodoxime vs Ciprofloxacin for Acute Cystitis

Completed · Not applicable

Conditions studied: Urinary Tract Infection

In brief

Urinary tract infection (UTI) is a very common problem in young healthy women, afflicting approximately one-half of women by their late 20s. One of the most common antibiotics used to treat UTIs is ciprofloxacin, usually for a total of three days. However, increasing resistance to this antibiotic has raised concerns about its overuse for cystitis and generated interest in alternative agents. An alternative antibiotic which is approved for use in UTIs is cefpodoxime. However, there are few studies evaluating the efficacy and tolerance of this compound when given in a 3-day regimen as is commonly used for treatment of UTI. The major purpose of this study is to assess the efficacy and tolerance of a 3-day regimen of cefpodoxime versus ciprofloxacin for treatment of acute uncomplicated cystitis.

Key facts

Study ID

NCT00194532

Run by

University of Washington

People needed

300

Starts

2005-06-01

Expected to finish

2009-02-01

Last updated by the study team

2014-06-10

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Nonpregnant females in good general health with symptoms of acute cystitis

You may not qualify if…

• Pregnant,lactating, or not regularly contracepting: known anatomic abnormalities of the urinary tract; use of prophylactic antibiotics; history of allergy or intolerance to any of the study drugs; recent (>2 weeks)exposure to an oral or parenteral antimicrobial; or history of UTI in the previous 1 month

Where it is running

• University of Miami Miller School of Medicine — Miami, Florida, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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