Psychosocial/Behavioral Intervention in Post-Stroke Depression

Completed · Not applicable

Conditions studied: Stroke

In brief

The primary aim of this study is to determine the effect of a nurse-delivered psychosocial/behavioral intervention on reduction of depression in community dwelling post-stroke patients. We expect the combined behavioral and pharmacologic intervention to be more effective than pharmacotherapy alone in sustaining the improvement in depression for the experimental group. Secondary aims are to examine the effect of the psychosocial/behavioral intervention time course and sustainability of response to treatment, effect on limitations in ability, limitation in participation and overall stroke impact in community-dwelling post-stroke patients, and to compare ischemic stroke survivors who are and are not depressed within the first four months following stroke by their 5-HTTLPR genotypes (s/s, s/l, or l/l).

Key facts

Study ID

NCT00194454

Run by

University of Washington

People needed

101

Starts

2002-03-01

Expected to finish

2008-02-01

Last updated by the study team

2008-09-23

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ischemic stroke within previous 4 months Screens positive for depressive symptoms by Geriatric Depression Scale Able to provide informed consent -

You may not qualify if…

• Subarachnoid or intracranial hemorrhagic stroke Global aphasia Reduced level of consciousness (GCS <15)

Where it is running

• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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