Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing

Completed · Not applicable

Conditions studied: Traumatic Brain Injury, Subarachnoid Hemorrhage

In brief

The aim of the initial proposal was to evaluate, in the context of optimal medical management, the impact of a bedside system of cerebral perfusion pressure (CPP) information feedback on nursing moment-to-moment management of CPP, and the relationship of that management to patient functional outcome at discharge, 3 and 6 months. The primary hypothesis being tested is that Glasgow Outcome Score (GOS) 6 months post acute care discharge will be significantly better in those monitored with the continuous CPP display. In the second phase of the study the adult study will be extended to children to determine if there is a critical threshold for CPP in children following brain injury based on their outcome at 3, 6, and 12 months. The primary outcome measure is the GOS at 12 months post-injury. The GOS, Behavior Rating Inventory of Executive Function, and PedsQOL will also be assessed at 3, 6, \& 12 months, and the Adaptive Behavior Assessment System at 3 and 6 months post-injury. In addition, the researchers will examine variability and complexity of physiologic measures, such as blood pressure, recorded during the intensive care unit stay of adults and children enrolled in the study. The researchers will study the association of these measures with risk for secondary brain injury and ability to predict differences in outcome. The researchers will also assess the value individuals place on varying outcomes following brain injury.

Key facts

Study ID

NCT00194441

Run by

University of Washington

People needed

260

Starts

1999-04-01

Expected to finish

2008-09-01

Last updated by the study team

2014-06-02

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Traumatic brain injury or subarachnoid hemorrhage
• Age 16 years or older
• Admitted to intensive care unit
• Invasive intracranial pressure and arterial blood pressure monitoring

You may not qualify if…

• Impending death
• Inclusion Criteria for second phase of study (determination of CPP threshold in children):
• Traumatic brain injury
• Age 15 years or younger
• Able to communicate by telephone
• Admitted to intensive care unit
• Intracranial pressure monitoring
• Inclusion Criteria for second phase of study (quality adjusted life years assessment):
• Hospitalized for a traumatic brain injury or subarachnoid hemorrhage at an academic medical center within the last 10 years
• Age 18 years or older at the time of hospitalization

Where it is running

• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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