Factor V Leiden Mutation and Implantation Failure

Completed

Conditions studied: Infertility

In brief

The purpose of this study is to determine whether inherited thrombophilias (tendency toward blood clotting) increase the risk of failure of the embryo to implant in IVF. The specific condition to be studied is the presence or absence of the Leiden mutation of the Factor V gene.

Key facts

Study ID

NCT00194350

Run by

University of Pennsylvania

People needed

399

Starts

2001-09-01

Expected to finish

2005-08-01

Last updated by the study team

2011-08-09

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women undergoing in-vitro fertilization with successful ovarian hyperstimulation, oocyte retrieval, and fertilization
• Transfer of at least 2 fresh embryos of Grade 2 (preembryo with blastomeres of equal size and <=10% cytoplasmic fragmentation) or better

You may not qualify if…

• Infertility due to uterine anatomic defect
• Current use of anticoagulant medication, such as heparin or aspirin
• Known presence of any other condition associated with increased risk of thrombosis

Where it is running

• University of Pennsylvania Reproductive Research Unit — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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